Regulation of voltage-dependent calcium channels by RGK proteins

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2013 English Publisher:Elsevier BVJournal:Biochimica et Biophysica Acta (BBA) - Biomembranes, volume 1,828, pages 1,644-1,654 (issn: 0005-2736,

Copyright policy )Funded by:NIH | Molecular Determinants of...

Authors: Yang, Tingting; Colecraft, Henry M.;

doi: 10.1016/j.bbamem.2012.10.005

pmid: 23063948

pmc: PMC4190112

Regulation of voltage-dependent calcium channels by RGK proteins

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Abstract

RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include four members - Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and are the most potent known intracellular inhibitors of high-voltage-activated Ca²⁺ (Ca(V)1 and Ca(V)2) channels. Here, we review and discuss the evidence in the literature regarding the functional mechanisms, structural determinants, physiological role, and potential practical applications of RGK-mediated inhibition of Ca(V)1/Ca(V)2 channels. This article is part of a Special Issue entitled: Calcium channels.

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Keywords

Gem, Sequence Homology, Amino Acid, Molecular Sequence Data, Biophysics, Rad, Voltage-dependent calcium channel, Cell Biology, RGK protein, Biochemistry, Rem, Animals, Humans, Rem2, Calcium, Amino Acid Sequence, Calcium Channels, Calcium Signaling, Ion Channel Gating, Monomeric GTP-Binding Proteins

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