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The DNA–DNA spacing in gemini surfactants–DOPE–DNA complexes

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2012 Germany Publisher:Elsevier BVJournal:Biochimica et Biophysica Acta (BBA) - Biomembranes, volume 1,818, pages 2,725-2,731 (issn: 0005-2736,

Authors: Pullmannova, P.; Funari, S. S.; Devinsky, F.; Uhrikova, D.;

doi: 10.1016/j.bbamem.2012.05.021

pmid: 22634275

The DNA–DNA spacing in gemini surfactants–DOPE–DNA complexes

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Abstract

Gemini surfactants from the homologous series of alkane-α,ω-diyl-bis(dodecyldimethylammonium bromide) (CnCS12, number of spacer carbons n=2-12) and dioleoylphosphatidylethanolamine (DOPE) were used for cationic liposome (CL) preparation. CLs condense highly polymerized DNA creating complexes. Small-angle X-ray diffraction identified them as condensed lamellar phase L(α)(C) in the studied range of molar ratios CnGS12/DOPE in the temperature range 20-60°C. The DNA-DNA distance (d(DNA)) is studied in dependence to CnGS12 spacer length and membrane surface charge density. The high membrane surface charge densities (CnGS12/DOPE=0.35 and 0.4mol/mol) lead to the linear dependence of d(DNA) vs. n correlating with the interfacial area of the CnGS12 molecule.

Country

Germany

Related Organizations

Deutsches Elektronen-Synchrotron DESY
Germany
Helmholtz Association of German Research Centres
Germany
Comenius University
Slovakia

Keywords

info:eu-repo/classification/ddc/570, Surface-Active Agents: chemistry, Phosphatidylethanolamines, Biophysics, Dioleoylphosphatidylethanolamine, 1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine, Cell Biology, DNA, Phosphatidylethanolamines: chemistry, Biochemistry, Surface-Active Agents, X-Ray Diffraction, DNA: chemistry, Small angle X-ray diffraction, Scattering, Small Angle, Gemini surfactant

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