Regulation of CXCR4 signaling
Copyright policy )Regulation of CXCR4 signaling
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome. Importantly, the involvement of CXCR4 in cancer metastasis and WHIM syndrome appears to be due to dysregulation of the receptor leading to enhanced signaling. Herein we review what is currently known regarding the regulation of CXCR4 and how dysregulation contributes to disease progression.
- Thomas Jefferson University United States
- Thomas Jefferson University United States
CXCR4, Receptors, CXCR4, Molecular Sequence Data, Biophysics, Immunologic Deficiency Syndromes, Cell Biology, Biochemistry, WHIM syndrome, Signaling, Receptors, G-Protein-Coupled, Gene Expression Regulation, Neoplasms, Receptor regulation, Humans, Amino Acid Sequence, Phosphorylation, Cancer, Signal Transduction
CXCR4, Receptors, CXCR4, Molecular Sequence Data, Biophysics, Immunologic Deficiency Syndromes, Cell Biology, Biochemistry, WHIM syndrome, Signaling, Receptors, G-Protein-Coupled, Gene Expression Regulation, Neoplasms, Receptor regulation, Humans, Amino Acid Sequence, Phosphorylation, Cancer, Signal Transduction
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