descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2006 English Publisher:Elsevier BVJournal:Biochimica et Biophysica Acta (BBA) - Biomembranes, volume 1,758, pages 1,957-1,977 (issn: 0005-2736,

Authors: Delgado, Antonio; Casas, Josefina; Llebaria, Amadeu; Abad, José Luís; Fabrias, Gemma;

doi: 10.1016/j.bbamem.2006.08.017

pmid: 17049336

Inhibitors of sphingolipid metabolism enzymes

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Abstract

Sphingolipids are a family of lipids that play essential roles both as structural cell membrane components and in cell signalling. The cellular contents of the various sphingolipid species are controlled by enzymes involved in their metabolic pathways. In this context, the discovery of small chemical entities able to modify these enzyme activities in a potent and selective way should offer new pharmacological tools and therapeutic agents.

Related Organizations

University of Barcelona
Spain

Keywords

Sphingolipids, Inhibitor, Biophysics, Serine C-Palmitoyltransferase, Cell Biology, Biosynthesis, Biochemistry, Amidohydrolases, Phosphotransferases (Alcohol Group Acceptor), Metabolism, Enzyme, Ceramidases, Enzyme Inhibitors, Oxidoreductases

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