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Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
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Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Article . 2006 . Peer-reviewed
License: Elsevier TDM
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Biochimica et Biophysica Acta
Article . 2007
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/j.b...
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Article . 2022
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Regulation of Smad activities

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2006 United States English Publisher:Elsevier BVJournal:Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, volume 1,759, pages 503-513 (issn: 0167-4781, Copyright policy )
Authors: Xu, Lan;

doi: 10.1016/j.bbaexp.2006.11.001

pmid: 17182123

pmc: PMC1805629

handle: 20.500.14038/39257

Regulation of Smad activities

Abstract

TGF-beta (Transforming Growth Factor-beta) cytokines employ Smad proteins as the intracellular mediator of signaling. Upon TGF-beta stimulation, the cytoplasmic Smads become phosphorylated and consequently accumulate in the nucleus to regulate target gene expression. The cytoplasm-to-nucleus redistribution of Smads, as well as the ability of Smads to activate or repress gene transcription, is under multiple layers of regulation by factors not limited to TGF-beta. With recent advance in the knowledge of regulatory factors impinged on Smads, we are beginning to understand the complexity in cellular responses to TGF-beta.

Country
United States
Related Organizations
Keywords

Cell Nucleus, Life Sciences, Biological Transport, Smad Proteins, Biological, Models, Biological, Smad Proteins, Receptor-Regulated, Models, Transforming Growth Factor beta, Medicine and Health Sciences, Animals, Humans, Receptor-Regulated, Phosphorylation, Smad4 Protein

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 89
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
89
Top 10%
Top 10%
Top 10%
bronze