Mitochondrial potassium channels: From pharmacology to function
Copyright policy )Mitochondrial potassium channels: From pharmacology to function
Mitochondrial potassium channels, such as ATP-regulated or large conductance Ca2+ -activated and voltage gated channels were implicated in cytoprotective phenomenon in different tissues. Basic effects of these channels activity include changes in mitochondrial matrix volume, mitochondrial respiration and membrane potential, and generation of reactive oxygen species. In this paper, we describe the pharmacological properties of mitochondrial potassium channels and their modulation by channel inhibitors and potassium channel openers. We also discuss potential side effects of these substances.
Potassium Channels, Diazoxide, Biophysics, Cell Biology, Biochemistry, Potassium channels, Membrane Potentials, Mitochondria, Potassium channel openers, Potassium Channels, Calcium-Activated, Adenosine Triphosphate, Sulfonylurea, Potassium Channels, Voltage-Gated, Potassium Channel Blockers, Animals, Humans, Calcium, Ion Channel Gating
Potassium Channels, Diazoxide, Biophysics, Cell Biology, Biochemistry, Potassium channels, Membrane Potentials, Mitochondria, Potassium channel openers, Potassium Channels, Calcium-Activated, Adenosine Triphosphate, Sulfonylurea, Potassium Channels, Voltage-Gated, Potassium Channel Blockers, Animals, Humans, Calcium, Ion Channel Gating
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