In this paper, the application of three well-known multi-objective optimization algorithms to water distribution network (WDN) optimum design has been considered. Non-dominated sorting genetic algorithm II (NSGA-II), Multi-objective differential evolution (MODE) and Multi-objective particle swarm optimization (MOPSO) algorithms are applied to benchmark mathematical test function problems for evaluating the performance of these algorithms. The Accuracy and computational runtime are the two indicators used for the comparison of these three algorithms. The optimization results of mathematical test functions show that all three algorithms were able to accurately produce Pareto Front, but the computational time of MODE algorithm to achieve the optimal solutions is lower than the two other algorithms. Then, the discussed algorithms have been used to optimize the WDN design problem. Comparison of the generated solutions on the Pareto Front for WDN design shows that the obtained Pareto Front of MODE is more accurate and faster. Keywords: Multi-objective optimization, Genetic algorithm, Differential evolution, Particle swarm, Water distribution design