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Microbial transformation of lovastatin by Beauveria bassiana

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2012 English Publisher:Elsevier BVJournal:Acta Pharmaceutica Sinica B, volume 2, pages 300-305 (issn: 2211-3835, Copyright policy )
Authors: Lirui Qiao; Dan Xie; Quan Liu; Jianhua Zou; Zhufang Shen; Jungui Dai;

doi: 10.1016/j.apsb.2012.04.001

Microbial transformation of lovastatin by Beauveria bassiana

Abstract

AbstractMicrobial transformation of lovastatin (1) by resting cells of a filamentous fungus, Beauveria bassiana AS 3.4270, yielded five metabolites (2–6), which were unambiguously characterized by various spectroscopic data analyses. The occurred reactions included hydroxylation, lactone hydrolysis and methylation. The inhibitory effects of all metabolites on the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase were evaluated. Of the five compounds, 4 exhibited comparable inhibitory effect to lovastatin on the HMG-CoA reductase with IC50 value of 2.2μM, and inhibitory rate of 81.4%.

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Keywords

Microbial transformation, HMG-CoA reductase, Resting cells, Therapeutics. Pharmacology, RM1-950, Lovastatin, Beauveria bassiana AS 3.4270

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
10
Average
Average
Top 10%
gold