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Antiviral drug resistance

Name: Antiviral drug resistance
Creator: Douglas D. Richman
Keywords: Evolution, Molecular, 0301 basic medicine, Viral Proteins, 0303 health sciences, 03 medical and health sciences, Drug Resistance, Viral, Mutation, HIV-1, Humans, Orthomyxoviridae

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2006Publisher:Elsevier BVJournal:Antiviral Research, volume 71, pages 117-121 (issn: 0166-3542,

Authors: Douglas D. Richman;

doi: 10.1016/j.antiviral.2006.03.004

pmid: 16621040

Antiviral drug resistance

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Abstract

Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to discover the functions of several viral proteins and to provide insights into viral evolution and fitness. Drug resistance has also become a standard component of both the preclinical and clinical drug development process. For HIV and increasingly for other viruses drug resistance testing has become standard-of-care in clinical practice. A few selected examples are provided to illustrate each of these points.

Related Organizations

University of California, San Diego
United States

Keywords

Evolution, Molecular, Viral Proteins, Drug Resistance, Viral, Mutation, HIV-1, Humans, Orthomyxoviridae, Antiviral Agents, Herpesviridae

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	196
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%