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Effect of phosphodiesterase inhibitors in the bladder

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2015 English Publisher:Elsevier BVJournal:Asian Journal of Urology, volume 2, pages 33-37 (issn: 2214-3882,

Authors: Aizaz Ali; Steven A. Kaplan; Claire Dunphy; Bilal Chughtai;

doi: 10.1016/j.ajur.2015.04.014

pmid: 29264117

pmc: PMC5730687

Effect of phosphodiesterase inhibitors in the bladder

- Summary
- Subjects
- Metrics

Abstract

Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, K-channel modulated pathways, and the l-cysteine/H2S pathway. PDE5 inhibitors exert their effect in muscle cells, nerve fibers, and interstitial cells (ICs). The use of PDE5 inhibitors led to improvement in LUTS. This included urodynamic parameters. PDE5 inhibitors may play a significant role in LUTS due to their effect on the bladder rather than the prostate.

Related Organizations

Cornell University
United States
Weill Cornell Medical College in Qatar
Qatar

Keywords

Lower urinary tract symptoms (LUTS), cAMP, NO/cGMP, RC870-923, Overactive bladder syndrome (OAB), Phosphodiesterase type 5 inhibitors, Diseases of the genitourinary system. Urology, Article

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	6
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average