Autism risk in small- and large-for-gestational-age infants
Copyright policy )Autism risk in small- and large-for-gestational-age infants
We sought to determine whether small-for-gestational age (SGA) and large-for-gestational age (LGA) birthweights increase autism risk.This was a retrospective cohort analysis comparing children with autism (n = 20,206) within a birth cohort (n = 5,979,605). Stratification by sex and birthweight percentile (SGA, 10th to 95th percentile) preceded Cochran-Mantel-Haenszel analysis for GA effect, and multivariate analysis.Autism risk was increased in preterm SGA (95th percentile) infants 39-41 weeks (aOR, 1.16; 95% CI, 1.08-1.26), but was decreased in preterm LGA infants 23-31 weeks (aOR, 0.45; 95% CI, 0.21-0.95).SGA was associated with autism in preterm infants, while LGA demonstrated dichotomous risk by GA, with increased risk at term, and decreased risk in the premature infants. These findings likely reflect disparate pathophysiologies, and should influence prenatal counseling, pediatric autism screening, and further autism research.
- University of Colorado Cancer Center United States
- Sutter Medical Center United States
- Center For Policy Research United States
- University of California, Davis United States
Male, Risk, Infant, Newborn, Gestational Age, Infant, Premature, Diseases, California, Infant, Small for Gestational Age, Birth Weight, Humans, Female, Autistic Disorder, Infant, Premature, Retrospective Studies
Male, Risk, Infant, Newborn, Gestational Age, Infant, Premature, Diseases, California, Infant, Small for Gestational Age, Birth Weight, Humans, Female, Autistic Disorder, Infant, Premature, Retrospective Studies
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).115 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!