In this article, we will describe how to analyze binary data from matched studies in orthodontics. We have previously discussed matched analysis for paired binary data (McNemar test), but now we will focus on the use of regression methods to model our data.1 The idea is the same as with simple logistic regression models for binary data2,3; however, we must remember that the observations are not independent, and participants in different treatment groups have been matched for at least 1 characteristic, and this must be taken into account in the analysis.