The purpose of this paper is to stimulate interest within the civil engineering research community for developing the next generation of applied artificial neural networks. In particular, it identifies what the next generation of these devices needs to achieve, and provides direction in terms of how their development may proceed. An analysis of the current situation indicates that progress in the development of artificial neural network applications has largely stagnated. Suggestions are made for advancing the field to the next level of sophistication and application, using genetic algorithms and related techniques. It is shown that this approach will require the design of some very sophisticated genetic coding mechanisms in order to develop the required higher-order network structures, and will utilize development mechanisms observed in nature such as growth, self-organization, and multi-stage objective functions. The capabilities of such an approach and the way in which they can be achieved are explored with reference to the problems of: (a) determining truck attributes from the strain envelopes they induce in structural members when crossing a bridge, and; (b) developing a decision support system for dynamic control of industrialized manufacturing of houses.