Vehicular Ad Hoc Networks (VANETs) are emerging as a very useful tool for gathering, processing, and providing data to vehicles and passengers. It is expected that vehicles equipped with a variety of sensors will play a determining role in Intelligent Transportation System (ITS) and Smart City applications. With the evolution of VANET services comes the need for solutions to increase the availability of content to users. To this end, we propose a Geo-Localized Origin-Destination-based Content Replication (GO-DCR) solution that relies on vehicles' origin and destination points to decide which of them are more appropriate to replicate content inside a region of interest. We compare GO-DCR with two existing solutions through extensive simulations. The results show that GO-DCR increases content availability and reduces the cost of delivery.