When attention is oriented to a peripheral visual event, observers respond faster to stimuli presented at a cued location than at an uncued location. Following initial reaction time facilitation responses are slower to stimuli subsequently displayed at the cued location, an effect known as inhibition of return (IOR). Both facilitatory and inhibitory effects have been extensively investigated in two-dimensional space. Facilitation has also been documented in three-dimensional space, however the presence of IOR in 3D space is unclear, possibly because IOR has not been evaluated in an empty 3D space. Determining if IOR is sensitive to the depth plane of stimuli or if only their bi-dimensional location is inhibited may clarify the nature of the IOR. To address this issue, we used an attentional cueing paradigm in three-dimensional (3D) space. Results were obtained from fourteen participants showed IOR components in 3D space when binocular disparity was used to induce depth. We conclude that attentional orienting in depth operates as efficiently as in the bi-dimensional space.