The Simon effect refers to the finding that faster responses are made to non-spatial stimulus features (e.g., color) when the positions of stimulus and response correspond than when they do not correspond. The usual explanation is that a spatial stimulus code automatically activates a corresponding spatial response code. Recently, however, the Simon effect has also been observed in vocal responses. The present study investigated the properties of Simon effects in the vocal modality. Experiment 1 compared horizontal and vertical Simon effects in vocal responses and found similar patterns of sequential modulations, but different time-courses. Yet the observed results are similar to those described in the literature for manual Simon effects. Experiments 2 and 3 used a dual-task procedure to investigate the impact of manual response codes on the encoding of irrelevant location and the initiation of vocal responses, respectively. Results suggest close links between manual response codes and conceptually corresponding vocal response codes.