The roles of microphthalmia-associated transcription factor and pigmentation in melanoma

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2014 English Publisher:Elsevier BVJournal:Archives of Biochemistry and Biophysics, volume 563, pages 28-34 (issn: 0003-9861,

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Authors: Jennifer J, Hsiao; David E, Fisher;

doi: 10.1016/j.abb.2014.07.019

pmid: 25111671

pmc: PMC4336945

The roles of microphthalmia-associated transcription factor and pigmentation in melanoma

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Abstract

MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage survival. Pigmentation itself plays an important role as the interface between genetic and environmental factors that contribute to melanoma.

Related Organizations

Harvard University
United States
Massachusetts General Hospital
United States

Keywords

Melanins, Microphthalmia-Associated Transcription Factor, Skin Neoplasms, Carcinogenesis, Cell Survival, Pigmentation, Cell Cycle, Oxidative Stress, Cell Transformation, Neoplastic, Cell Movement, Animals, Humans, Melanocytes, Neoplasm Invasiveness, Melanoma

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