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Archives of Biochemistry and Biophysics
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Archives of Biochemistry and Biophysics
Article . 2012 . Peer-reviewed
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Archives of Biochemistry and Biophysics
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Allosteric regulation of phenylalanine hydroxylase

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2012Publisher:Elsevier BVJournal:Archives of Biochemistry and Biophysics, volume 519, pages 194-201 (issn: 0003-9861, Copyright policy )
Authors: Paul F. Fitzpatrick;

doi: 10.1016/j.abb.2011.09.012

pmid: 22005392

pmc: PMC3271142

Allosteric regulation of phenylalanine hydroxylase

Abstract

The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin. Phosphorylation of Ser16 lowers the concentration of phenylalanine for activation. This review discusses the present understanding of the molecular details of the allosteric regulation of the enzyme.

Related Organizations
Keywords

Allosteric Regulation, Animals, Humans, Phenylalanine Hydroxylase, Phosphorylation

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 58
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
58
Top 10%
Top 10%
Top 10%
bronze