descriptionPublicationkeyboard_double_arrow_right Article 01 May 2008 English Publisher:Elsevier BVJournal:Archives of Biochemistry and Biophysics, volume 473, pages 183-187 (issn: 0003-9861,

Authors: Kassem, Moustapha; Abdallah, Basem; Saeed, Hamid;

doi: 10.1016/j.abb.2008.03.028

pmid: 18406334

Osteoblastic cells: Differentiation and trans-differentiation

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Abstract

The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that can provide insight into mechanisms of bone maintenance and also novel pharmacological targets to increase osteoblast differentiation and consequently bone formation.

Related Organizations

University of Southern Denmark
Denmark
Odense University Hospital
Denmark

Keywords

Osteoblasts, Bone Marrow Cells, Cell Differentiation, Mesenchymal Stem Cells, Osteogenesis, Cell Transdifferentiation, Adipocytes, Animals, Humans, Cell Lineage

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