Publisher Summary A virtually infinite number of chemicals and chemical mixtures are potentially present on hazardous waste sites. Remedial action personnel must be properly protected to prevent short- and long-term disabilities related to these hazards. Engineering controls, administrative controls, good work practices, and personnel protective equipment (PPE) are the routes to such protection. This chapter focuses on PPE as a means for minimizing or eliminating deleterious health effects because of contact with chemicals. Principally, these health effects are dependent on the route of exposure, the duration of the exposure, and the toxicity of the chemical. The routes of exposure may be ingestion, inhalation, and skin contact. Proper selection of PPE requires careful assessment of the risk hazard. This assessment includes the chemicals involved, the skills of the workers, the tasks, and the duration of potential exposures. PPE must then be selected on the basis of its demonstrated performance under such conditions. With regard to clothing, chemical resistance is a key concern and it must be recognized that there is no universal barrier material. Workers must be instructed as to the use and the limitations of PPE.