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Anti-inflammatory Agents

Name: Anti-inflammatory Agents
Keywords: 3. Good health

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Patent 01 Jan 2007 English Publisher:Elsevier BV

Authors: Paola Allavena; Maurizio D'Incalci; Glynn Faircloth;

doi: 10.1016/b978-008045344-6.50006-9 , 10.1016/b978-008045344-6/50006-9

Anti-inflammatory Agents

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Abstract

We have found anti-inflammatory activity in the ecteinascidin compounds. Such compounds have been widely described, and may have the following general formula (I): wherein: R 5 is OH, alkoxy or alkanoyloxy; R 6 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R 12 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R 16 is hydrogen, alkyl, alkenyl, alkynyl or aryl; R 17 is OH, alkoxy or alkanoyloxy; R 18 is OH, alkoxy or alkanoyloxy; R 21 is H, OH, CN or another nucleophilic group; and R a is hydrogen and R b is optionally substituted amino, or R a with R b form a carbonyl function ═O, or R a , R b and the carbon to which they are attached form a tetrahydroisoquinoline group.

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