This chapter describes the reproductive and developmental toxicity of herbicides and fungicides in humans and animals. Numerous chemicals including herbicides and fungicides are ubiquitous in the environment. Some of them obviously have the potential to cause reproductive and developmental toxicity. Most of the data presently available have been derived from experiments performed on laboratory species or in vitro models. Epidemiological studies clearly indicate that exposure to these chemicals may be associated with menstrual cycle disturbances, reduced fertility, prolonged time to pregnancy, spontaneous abortions, stillbirths, and developmental defects both in animals and humans. The number of herbicides and fungicides having endocrine disruptor properties is increasing. Several such chemicals are still under investigation. Therefore, several herbicides and fungicides are known to cause reproductive toxicity, developmental problems, and endocrine disruptions in animals and humans.