Genomics of Brain Aging: Nuclear and Mitochondrial Genomes☆
Genomics of Brain Aging: Nuclear and Mitochondrial Genomes☆
In recent times, the study of genomic changes associated with age has been improved by the introduction of microarray technology, which allows the detection of whole-genome expression profiles using single samples. Nuclear transcriptional modifications associated with the physiology and pathology of brain aging indicate the involvement of multiple relevant pathways. Several of these pathways are shared by cells bearing mitochondrial DNA mutations, which are known to increase with age. Taken together, these studies may help to define the role of mitochondria in the process of aging and eventually to identify a genomic fingerprint of brain aging. © 2009 Elsevier Ltd All rights reserved.
- University of Milano-Bicocca Italy
- University of California, Davis United States
- University of Milan Italy
Apoptosis; Brain aging; Calcium dysfunction; Caloric restriction; Microarray; Mitochondrial deletions; Mitochondrial mutations; Neurodegeneration; Oxidative stress; Transcriptional profile;
Apoptosis; Brain aging; Calcium dysfunction; Caloric restriction; Microarray; Mitochondrial deletions; Mitochondrial mutations; Neurodegeneration; Oxidative stress; Transcriptional profile;
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!