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Varenicline

Name: Varenicline
Keywords: Chromatography, X-Ray Diffraction, Quinoxalines, Spectrum Analysis, Animals, Humans, Smoking Cessation, Nicotinic Agonists, Benzazepines, Varenicline

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 2012Publisher:Elsevier BV

Authors: Mohammed Gabr Kassem; Abdullah M. Al Hossaini;

doi: 10.1016/b978-0-12-397220-0.00010-6

pmid: 22469324

Varenicline

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Abstract

Varenicline is a novel agent that is centrally acting partial nicotinic acetylcholine receptor antagonist. It has both agonistic and antagonistic properties that together are believed to account for reduction of craving and withdrawal as well as blocking the rewarding effects of smoking. Its targeted mechanism of action,better efficacy and tolerability makes varenicline a useful therapeutic option for smoking cessation. Several methods of varenicline synthesis are included in this profile. UV spectroscopy of varenicline showed a lmax of approximately 235nm, whereas IR spectroscopy ,NMR and fragmentation pattern of varenicline were reported. In addition, pharmacology and methods for the analysis of varenicline are also described.

Related Organizations

King Saud University
Saudi Arabia

Keywords

Chromatography, X-Ray Diffraction, Quinoxalines, Spectrum Analysis, Animals, Humans, Smoking Cessation, Nicotinic Agonists, Benzazepines, Varenicline

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	2
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

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