Inherited deficiencies of factors II, V and X (FII, FV, FX) are rare (estimated frequencies are: FII, 1 in 2,000,000; FV, 1 in 1,000,000; and FX, 1 in 500,000). Patients who are homozygous or compound heterozygous for defects in the FII, FV or FX genes can have moderate to severe bleeding symptoms, with patients having FX deficiency more likely to manifest severe symptoms. Given the small number of cases reported in the literature, the genotype/phenotype correlation is difficult to ascertain; however, in general, the lower the levels of factor, the more severe the bleeding. Bleeding episodes for these factor deficiencies can be treated with plasma products or for FII and FIX prothrombin complex concentrates. Platelets can also be given for FV deficiency, potentially aiding in hemostasis by delivering FV to the site of bleeding.