Powered by OpenAIRE graph
Found an issue? Give us feedback
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

Lipid Microdomains—Structure, Function, and Controversies

Authors: Lucyna Mrówczyńska;

Lipid Microdomains—Structure, Function, and Controversies

Abstract

Abstract Lipid microdomains, referred to as membrane microdomains, membrane rafts, or lipid rafts, are the highly dynamic nanoscale liquid-ordered, sphingolipid-, and sterol-rich domains in the plasma membrane. Lipid microdomains recruit specific proteins and form sophisticated lipid–protein assemblies as the result of lipid–lipid, lipid–protein, and protein–protein interactions that are involved in many cellular processes, including signaling pathways, endocytosis, and protein sorting. Moreover, lipid microdomains play a role in pathogenesis of various diseases. Resistance of cold nonionic detergent Triton X-100 to solubilization is used as a common tool to study lipid rafts structure; however, detergent-based artifacts were observed. Despite a vast amount of experimental work in which the noninvasive, detergent-free methods were used, the facts concerning the structure and functions of lipids microdomains in living cells are still disputable. This chapter consists of selected topics on current knowledge on membrane microdomains enriched with controversial data, and it presents variety of factors responsible for the impressive dynamic of plasma membrane planar organization.

Related Organizations
  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    1
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Upload OA version
Are you the author? Do you have the OA version of this publication?