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The Preparation of Fluorine-18 Labelled Radiopharmaceuticals

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 1977Publisher:Elsevier BVJournal:The International Journal of Applied Radiation and Isotopes, volume 28, pages 53-65 (issn: 0020-708X,

Authors: A K, Horsch; K, Hudson; R W, Goulding; A J, Day;

doi: 10.1016/b978-0-08-021344-6.50012-4 , 10.1016/0020-708x(77)90160-0

pmid: 323160

The Preparation of Fluorine-18 Labelled Radiopharmaceuticals

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Abstract

Abstract Progress in the preparation of fluorine-18 labelled radiopharmaceuticals is reviewed. The pharmacology and design of 18F-labelled organic compounds of biomedical interest, production of the radionuclide and methods of labelling which have been used to date are discussed. Emphasis has been placed on the practical chemical problems encountered, together with the important fields of product purification and quality control.

Related Organizations

Imperial College Healthcare NHS Trust
United Kingdom
Hammersmith Hospital
United Kingdom

Keywords

Orotic Acid, Radioisotopes, Hippurates, Carboxylic Acids, Flucytosine, p-Fluorophenylalanine, Fluorine, Isotope Labeling, Barbiturates, Haloperidol, Fluorouracil, Amino Acids

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	54
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%