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Inositol lipids in cell signalling

Name: Inositol lipids in cell signalling
Creator: Robin F. Irvine
Keywords: 0301 basic medicine, 0303 health sciences, Phosphoric Diester Hydrolases, Inositol Phosphates, Receptors, Cytoplasmic and Nuclear, Receptors, Cell Surface, Second Messenger Systems, 03 medical and health sciences, Animals, Humans

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1992Publisher:Elsevier BVJournal:Current Biology, volume 2, page 228 (issn: 0960-9822,

Authors: Robin F. Irvine;

doi: 10.1016/0960-9822(92)90346-c , 10.1016/0955-0674(92)90035-b

pmid: 1318060

Inositol lipids in cell signalling

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Abstract

In the past year, major advances have been made in our understanding of the regulation of phosphoinositidase C, and of the action of the inositol trisphosphate receptor and how it may generate 'quantal' Ca2+ release. The functions of inositol tetrakisphosphate and of the 3-phosphorylated inositol lipids continue to generate controversy, but both may be well on the way towards some clarification. Finally, we may have to extend our concept of the inositide cycle to include an intranuclear signalling function.

Keywords

Phosphoric Diester Hydrolases, Inositol Phosphates, Receptors, Cytoplasmic and Nuclear, Receptors, Cell Surface, Second Messenger Systems, Animals, Humans, Inositol 1,4,5-Trisphosphate Receptors, Calcium, Calcium Channels, Signal Transduction

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	116
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%