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Genetic analysis of recombination in prokaryotes

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1992Publisher:Elsevier BVJournal:Current Biology, volume 2, page 584 (issn: 0960-9822,

Authors: Gary J. Sharples; Robert G. Lloyd;

doi: 10.1016/0960-9822(92)90155-4 , 10.1016/s0959-437x(05)80127-3

pmid: 1458021

Genetic analysis of recombination in prokaryotes

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Abstract

Bacteria provide a simple system for the genetic analysis of homologous recombination. More than twenty genes have been identified in Escherichia coli. The enzymatic activities associated with the products of many of these genes have been revealed by studies with model DNA substrates. It is now possible to pair homologous molecules in vitro and process these through defined intermediates into mature recombinants of the types predicted by genetic crosses.

Related Organizations

Nottingham Trent University
United Kingdom
Nottingham University Hospitals NHS Trust
United Kingdom
Queen's Medical Centre
United Kingdom

Keywords

DNA, Bacterial, Recombination, Genetic, Endodeoxyribonucleases, Exodeoxyribonuclease V, Bacteria, DNA Repair, Escherichia coli Proteins, Serine Endopeptidases, Rec A Recombinases, Exodeoxyribonucleases, Bacterial Proteins, Genes, Bacterial, Escherichia coli, DNA Damage

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