Utrophin: A potential replacement for dystrophin?
Copyright policy )Utrophin: A potential replacement for dystrophin?
This paper reviews the evidence that utrophin, the autosomally encoded protein related to dystrophin, may be capable of performing the same cellular functions as dystrophin. If this is the case, it may be possible to modify the regulation of utrophin expression as an alternative route to dystrophin gene therapy for sufferers of DMD and/or BMD.
- Oxford University Hospitals NHS Trust United Kingdom
- John Radcliffe Hospital United Kingdom
- Northamptonshire Healthcare NHS Foundation Trust United Kingdom
Adult, Utrophin, Muscles, Membrane Proteins, Gestational Age, Genetic Therapy, Muscular Dystrophy, Animal, Muscle Development, Muscular Dystrophies, Dystrophin, Cytoskeletal Proteins, Embryonic and Fetal Development, Mice, Mice, Neurologic Mutants, Gene Expression Regulation, Animals, Humans
Adult, Utrophin, Muscles, Membrane Proteins, Gestational Age, Genetic Therapy, Muscular Dystrophy, Animal, Muscle Development, Muscular Dystrophies, Dystrophin, Cytoskeletal Proteins, Embryonic and Fetal Development, Mice, Mice, Neurologic Mutants, Gene Expression Regulation, Animals, Humans
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