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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Bioorganic & Medicin...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Bioorganic & Medicinal Chemistry Letters
Article . 1996 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
Bioorganic & Medicinal Chemistry Letters
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Optimization of retro-thiorphan for inhibition of endothelin converting enzyme

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1996 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 6, pages 619-624 (issn: 0960-894X, Copyright policy )
Authors: W.X. Kozak; Paula Savage; Paivi Jaana Kukkola; Natalie A. Bilci; Arco Y. Jeng;

doi: 10.1016/0960-894x(96)00091-1

Optimization of retro-thiorphan for inhibition of endothelin converting enzyme

Abstract

Abstract The structural requirements of retro-thiorphan, N -[1 R , S -benzyl-2-mercaptoethyl]malonamic acid 2 , analogs for the inhibition of endothelin converting enzyme (ECE) were investigated. Although based on a single amino acid residue, N -[1 R -(1 H -indol-3-ylmethyl)-2-mercaptoethyl]-2-phenylacetamide 28 was found to be two times more potent than the widely utilized reference inhibitor phosphoramidon.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
11
Average
Average
Top 10%
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