descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1992 English Publisher:Elsevier BVJournal:Progress in Growth Factor Research, volume 4, pages 207-227 (issn: 0955-2235,

Authors: Dan Berg; Gina Holland; Donna M. Rennick;

doi: 10.1016/0955-2235(92)90020-i

pmid: 1307489

Interleukin 10: An overview

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Abstract

Since the original description of interleukin-10, a wealth of information concerning its biological properties has been gathered. Studies in vitro have rapidly identified both immunostimulatory and immunosuppressive activities for IL-10. Based on these findings, in vivo studies were initiated in a variety of animal disease models to assess the importance of these activities. This review will summarize the pleiotropic properties of IL-10 and will survey current research regarding the potential of IL-10 to regulate acute and chronic inflammatory reactions.

Keywords

Animals, Humans, T-Lymphocytes, Helper-Inducer, Hematopoietic Stem Cells, Hematopoiesis, Interleukin-10

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