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Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

Name: Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins
Creator: Gary M. Bokoch
Keywords: 0301 basic medicine, 0303 health sciences, Neutrophils, NADPH Oxidases, Guanosine Diphosphate, Models, Biological, rac GTP-Binding Proteins, 3. Good health, Chemotaxis, Leukocyte, 03 medical and health sciences

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1994Publisher:Elsevier BVJournal:Current Opinion in Cell Biology, volume 6, pages 212-218 (issn: 0955-0674,

Authors: Gary M. Bokoch;

doi: 10.1016/0955-0674(94)90138-4

pmid: 8024812

Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

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Abstract

Recent progress in our understanding of the regulation of the phagocyte NADPH oxidase by the Rac GTP-binding protein(s) has provided the first detailed glimpse into the mechanisms of leukocyte regulation by a small GTP-binding protein. Studies over the past year have indicated that the activity of the NADPH oxidase can be modulated by regulation of the GTP/GDP state of Rac. Proteins exist in leukocytes that are able to modify GTP-binding protein function in this manner, and their activity may be regulated by signals generated upon phagocyte stimulation.

Related Organizations

Scripps Research Institute
United States

Keywords

Neutrophils, NADPH Oxidases, Guanosine Diphosphate, Models, Biological, rac GTP-Binding Proteins, Chemotaxis, Leukocyte, Phagocytosis, GTP-Binding Proteins, Animals, Homeostasis, Humans, NADH, NADPH Oxidoreductases, Guanosine Triphosphate

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	146
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%