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Liposomes for the transformation of eukaryotic cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1991 English Publisher:Elsevier BVJournal:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, volume 1,097, pages 1-17 (issn: 0925-4439,

Authors: Peter Hug; Richard G. Sleight;

doi: 10.1016/0925-4439(91)90016-3

pmid: 1859848

Liposomes for the transformation of eukaryotic cells

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Abstract

Gene therapy of human disease is a method of treatment under active development. DNA-loaded liposomes exhibit great promise for use in this field. Liposome-based transfection vectors have many inherent advantages that will likely lead to their wide in vivo use. Vectors with low toxicity and a high degree of targetability can now be easily prepared. These vectors are also free of the length constraints governing retroviral vectors. In this review we discuss recent developments in the use of liposomes for transfection of eukaryotic cells.

Related Organizations

University System of Ohio
United States
University of Cincinnati
United States
University of Cincinnati Medical Center
United States

Keywords

Retroviridae, Transformation, Genetic, Liposomes, DNA, Recombinant, Animals, Humans, Genetic Therapy

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%