Abstract The skin may be the most commonly affected organ in patients with human immunodeficiency virus (HIV) disease. This may be manifested in a number of different ways, ranging from pruritus and generalized xerosis to severe fulminating infections with opportunistic agents. It is incumbent upon all clinicians to be cognizant of this fact, as inspection may lead to early diagnosis of HIV disease and/or early recognition of severe life-threatening illnesses. It has become increasingly recognized that many HIV-related inflammatory dermatoses may be unusual and not correspond precisely to well-described conditions. 1 The clinician must be aware of this, as treatment response may be poor or delayed. Furthermore, patients may be quite symptomatic and suffer worsened quality of life. In this article, two of these conditions will be addressed; specifically, the atopic dermatitis-like and seborrheic dermatitis-like eruptions commonly seen in this patient population.