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Antihepatotoxic actions of tannins

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1985 English Publisher:Elsevier BVJournal:Journal of Ethnopharmacology, volume 14, pages 19-29 (issn: 0378-8741,

Authors: Kiso Yoshinobu; Okuda Takuo; Yoshida Takashi; Hatano Tsutomu; Hikino Hiroshi;

doi: 10.1016/0378-8741(85)90024-8

pmid: 4087919

Antihepatotoxic actions of tannins

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Abstract

The antihepatotoxic effects of tannin analogues were examined utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most tannins showed significant antihepatotoxic effects in these two assay systems. Hydrolyzable tannins generally exhibited an intense enzyme inhibitory action on glutamic-pyruvic transaminase while condensed tannins exerted a much less inhibitory action, although variations were observed depending on structure. Structure-activity relationships are discussed.

Related Organizations

Okayama University
Japan
Tohoku University
Japan

Keywords

Carbon Tetrachloride Poisoning, Animals, Alanine Transaminase, Galactosamine, Chemical and Drug Induced Liver Injury, Tannins, Cells, Cultured, Rats

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	44
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average