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Platelet-derived growth factor in Dupuytren's disease

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1992Publisher:Elsevier BVJournal:The Journal of Hand Surgery, volume 17, pages 317-323 (issn: 0363-5023,

Authors: Marie A. Badalamente; Steven P. Sampson; Shawn K. Grandia; Lawrence C. Hurst;

doi: 10.1016/0363-5023(92)90414-k

pmid: 1564283

Platelet-derived growth factor in Dupuytren's disease

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Abstract

This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.

Related Organizations

State University of New York at Potsdam
United States
Stony Brook University
United States

Keywords

Adult, Male, Platelet-Derived Growth Factor, Fibroblasts, Middle Aged, Hand, Immunohistochemistry, Dupuytren Contracture, Humans, Female, Fascia, Cell Division, Aged

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	52
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%