descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1993 English Publisher:Elsevier BVJournal:Medical Hypotheses, volume 40, pages 174-181 (issn: 0306-9877,

Authors: Joan Prat; M. Portero; Maria Josep Bellmunt; Reinald Pamplona;

doi: 10.1016/0306-9877(93)90207-7

pmid: 8502197

Mechanisms of glycation in atherogenesis

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Abstract

Non-enzymatic glycation may affect the arterial wall altering its connective tissue and promoting LDL accumulation. Its recognition by specific receptors and growth factor release, as well as possible alteration of DNA, may stimulate smooth muscle cell proliferation. Free radical generation may favour non-enzymatic PUFA degradation and quench NO, which would alter vascular relaxation. All of these aspects may participate in atherogenesis.

Related Organizations

University of Lleida
Spain

Keywords

Glycation End Products, Advanced, Glycosylation, Arteriosclerosis, Models, Cardiovascular, Arteries, Muscle, Smooth, Vascular, Lipoproteins, LDL, Glucose, Connective Tissue, Animals, Humans

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