descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1983 English Publisher:Elsevier BVJournal:General Pharmacology: The Vascular System, volume 14, pages 135-136 (issn: 0306-3623,

Authors: Ch. Owman; J. Hanko; Jan Erik Hardebo;

doi: 10.1016/0306-3623(83)90083-6

pmid: 6131008

Species variation in the cerebrovascular response to neurotransmitters and related vasoactive agents

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Abstract

Constrictory and dilatory responses of pial arteries to various receptor stimulants and modulators were evaluated in vitro and compared in rat, rabbit, cat and man. For the constrictory response, differences were noted especially in the rabbit, which responded strongly to histamine but poorly to noradrenaline and prostaglandin F2 alpha. Histamine was a prominent dilator, but only in rat and man. Isoprenaline induced effective vasodilation only in rat, and dopamine was efficient only in human pial arteries.

Related Organizations

Lund University
Sweden

Keywords

Neurotransmitter Agents, Vasodilator Agents, In Vitro Techniques, Muscle, Smooth, Vascular, Rats, Species Specificity, Cerebrovascular Circulation, Cats, Animals, Humans, Vasoconstrictor Agents, Rabbits

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