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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Biosystems
Article . 1971 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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The G-S-T theory of cellular differentiation

Authors: Harold. W. Manner;

The G-S-T theory of cellular differentiation

Abstract

Abstract Every cell in a developing embryo has the same genotype. The genes, identified as G1, G2.....Gn, are programmed to operate sequentially, G1 acting at time (T1), G2 at T2, and Gn at Tn. These genes will transcribe their message, however, only if they are in the immediate vicinity of the appropriate stimulus. These stimuli, S1, S2 .....Sn, are specific for the genes with the same subscript. If a gene is not “turned on” at the appropriate time, it loses its opportunity, and the ontire system shifts to the next time phase. This theory is discussed, in terms of both embryological data and as a working model for the design of future experiments.

Related Organizations
Keywords

Embryonic and Fetal Development, Time Factors, Genes, Transduction, Genetic, Animals, Cell Differentiation, Anura, Models, Biological, Chromosomes

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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