Distribution and disposition of morpholine in the rabbit
Copyright policy )Distribution and disposition of morpholine in the rabbit
The results of a variety of in vivo and in vitro experiments suggested that the kidneys were the primary route of elimination of morpholine in the rabbit. Morpholine was not bound to serum proteins and was excreted 90% unchanged. The concentration of [14C]morpholine in the renal cortex was 6.6 times the concentration in the blood, and in the renal medulla was 15.3 times the concentration in the blood 30 min after the intravenous injection of single boluses of labelled compound. The chemical appeared to be distributed mainly to the extracellular space, and its rate of elimination was enhanced by acidification of the urine.
- National Institutes of Health United States
- National Institute of Health Pakistan
- Research Triangle Park Foundation United States
- National Institute of Environmental Health Sciences United States
Male, Solubility, Morpholines, Animals, Bile, Tissue Distribution, Rabbits, Kidney, Lipid Metabolism
Male, Solubility, Morpholines, Animals, Bile, Tissue Distribution, Rabbits, Kidney, Lipid Metabolism
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