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Epidermal growth factor receptor ≠ nerve growth factor

Name: Epidermal growth factor receptor ≠ nerve growth factor
Creator: Lawrence R. Williams
Keywords: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1989Publisher:Elsevier BVJournal:Neurobiology of Aging, volume 10, pages 586-587 (issn: 0197-4580,

Authors: Lawrence R. Williams;

doi: 10.1016/0197-4580(89)90140-1

Epidermal growth factor receptor ≠ nerve growth factor

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Abstract

I am perplexed by the authors' complete lack of definition of neurotrophic factors. The agents Butcher and Woolf want to blame are neurite promoting factors, not neurotrophic factors. Treatment of Alzheimer's disease with NGF antagonists might instead exacerbate the death of both basal forebrain neurons and their cortical target neurons, accelerating the progress of dementia.

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Upjohn
United States

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