descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1987 English Publisher:Elsevier BVJournal:Peptides, volume 8, pages 123-126 (issn: 0196-9781,

Authors: H H, Suh; L F, Tseng; C H, Li;

doi: 10.1016/0196-9781(87)90175-6

pmid: 2952945

Beta-endorphin-(1–27) antagonizes beta-endorphin-induced hypothermia in mice

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Abstract

The effects of beta-endorphin and beta-endorphin-(1-27) on the body temperature of mice was studied at an ambient temperature of 10 degrees C. Intracerebroventricular injection of beta-endorphin (0.25-4 micrograms) and beta-endorphin-(1-27) (0.61 to 10 micrograms) caused a dose-related hypothermia. The duration of hypothermia induced by beta-endorphin-(1-27) was shorter than that induced by beta-endorphin. The hypothermia induced by 2 micrograms of beta-endorphin was attenuated by 5 micrograms of beta-endorphin-(1-27). Our results indicated that beta-endorphin-(1-27) is a partial agonist which produces a small degree of hypothermia and an antagonist which blocks the beta-endorphin-induced hypothermia.

Related Organizations

University of California, San Francisco
United States
United States Department of Veterans Affairs
United States
Medical College of Wisconsin
United States

Keywords

Male, Mice, Time Factors, beta-Endorphin, Animals, Endorphins, Peptide Fragments, Body Temperature

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