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The T genes in embryogenesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1994Publisher:Elsevier BVJournal:Trends in Genetics, volume 10, pages 280-286 (issn: 0168-9525,

Authors: Andreas Kispert; Bernhard G. Herrmann;

doi: 10.1016/0168-9525(90)90011-t

pmid: 7940757

The T genes in embryogenesis

- Summary
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- Related research
  (4)
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Abstract

Since its identification in 1927, the mouse T (Brachyury) locus has been implicated in mesoderm formation and notochord differentiation. Recent work has demonstrated that this gene encodes a putative transcription factor expressed specifically in nascent mesoderm and in the differentiating notochord. Homologous genes have been cloned from the frog Xenopus laevis, the zebrafish Brachydanio rerio and the ascidian Halocynthia roretzi. The T gene is an important tool for elucidating mesoderman and embryonic pattern formation.

Related Organizations

Max Planck Society
Germany
Max Planck Institute of Neurobiology
Germany

Keywords

Embryonic Induction, Fetal Proteins, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Gene Expression Regulation, Developmental, DNA-Binding Proteins, Mesoderm, Embryonic and Fetal Development, Mice, Animals, T-Box Domain Proteins, Brachyury Protein

4 Research products, page 1 of 1

T-box transcription factor T
2018IsRelatedTo
Brachyury, T-box transcription factor T
2018IsRelatedTo
Brachyury, isoform CRA_a
2017IsRelatedTo
Brachyury, T-box transcription factor T
2018IsRelatedTo

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