Regulation of immunoglobulin gene rearrangement and expression
Copyright policy )Regulation of immunoglobulin gene rearrangement and expression
The molecular genetic events leading to Ig expression and their control formed the topic of a recent EMBO workshop. This report by Michael Taussig, Martin Sims and Ulrich Krawinkel discusses contributions dealing with genes expressed in early pre-B cells, the mechanism of rearrangement, aberrant rearrangements seen in B cells of SCID mice, the feedback control of rearrangement as studied in transgenic mice, the control of Ig expression at the transcriptional and post-transcriptional levels, and class switching.
Gene Rearrangement, B-Lymphocytes, Mice, Enhancer Elements, Genetic, Gene Expression Regulation, Genes, Immunoglobulin, Animals, Mice, Mutant Strains, Feedback
Gene Rearrangement, B-Lymphocytes, Mice, Enhancer Elements, Genetic, Gene Expression Regulation, Genes, Immunoglobulin, Animals, Mice, Mutant Strains, Feedback
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