Studies on esterolytic activity of alternative complement component factor B
Copyright policy )Studies on esterolytic activity of alternative complement component factor B
Abstract Alternative complement component factor B was purified from human plasma and its esterolytic activity on various α-naphthylester derivatives was examined. Of these substrates, LeuAlaArg-naphthylester was the most susceptible. The K m value of factor B for this substrate was about 5·10 −4 M. 6-Amidino2-naphthyl-4-guanidinobenzoate inhibited the esterolytic activity of factor B. After activation of factor B, the esterolytic activity did not increase and the decayed form, Bb, cleaved the substrate to the same extent as factor B.
- Osaka University Japan
Enzyme Precursors, Kinetics, Complement Pathway, Alternative, Humans, Protease Inhibitors, Complement Activation, Complement Factor B, Substrate Specificity
Enzyme Precursors, Kinetics, Complement Pathway, Alternative, Humans, Protease Inhibitors, Complement Activation, Complement Factor B, Substrate Specificity
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