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Antiviral Research
Article
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PubMed Central
Other literature type . 1986
Data sources: PubMed Central
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Antiviral Research
Article . 1986 . Peer-reviewed
License: Elsevier TDM
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Antiviral Research
Article . 1986 . Peer-reviewed
Data sources: Crossref
Antiviral Research
Article . 1986
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Antiviral Research
Article
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Alphavirus replication in cultured cells and infected animals is inhibited by antiproteinase agents

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Aug 1986 English Publisher:Elsevier BVJournal:Antiviral Research, volume 6, pages 255-265 (issn: 0166-3542, Copyright policy )
Authors: A. V. Ovcharenko; Oleg P. Zhirnov; A. G. Bukrinskaya; S.Ya. Gaidamovich; E. E. Melnikova;

doi: 10.1016/0166-3542(86)90021-5

pmid: 2429615

pmc: PMC7134154

Alphavirus replication in cultured cells and infected animals is inhibited by antiproteinase agents

Abstract

The influence of different antiproteinase agents on alphavirus replication was examined. Sindbis virus multicycle replication in cultured cells was suppressed by N-tosyl-phenylalanine chloromethyl ketone (TPCK), an inhibitor of chymotrypsin-like proteinases, and by aprotinin, an inhibitor of a wide spectrum of proteinases. Antiviral activity of TPCK was also demonstrated in Sindbis virus-infected animals. Parenteral injections of TPCK in infected mice reduced virus titers in brain and blood. The possible mechanism(s) of antiviral action of the antiproteinase agents are discussed.

Keywords

Pharmacology, Tosylphenylalanyl Chloromethyl Ketone, Chick Embryo, Viral Plaque Assay, Tosyllysine Chloromethyl Ketone, Virus Replication, Antiviral Agents, Article, Amino Acid Chloromethyl Ketones, Mice, Aprotinin, Togaviridae Infections, Virology, Animals, Sindbis Virus, Cells, Cultured

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    		 7
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Average
Average
Average
Green
bronze
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