Abstract Premalignant and hematologic disorders are associated with more than 100 types of chromosome rearrangements. These rearrangements are listed here by the type of hematologic disorder and by breakpoints. Translocations predominate, followed by deletions. Duplications and isochromosomes that result in duplication are rare in hematologic diseases. Taking the locations of breakpoints in all types of neoplasms, 77% appear currently to be restricted to a single type of tumor, while 23% are shared by multiple types of neoplasms. Solid tumors tend to share breakpoint locations, particularly with other solid tumors.