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IgC Fc fragments induce B cell differentiation and immunoglobulin secretion

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1989Publisher:Elsevier BVJournal:Immunology Letters, volume 23, pages 161-162 (issn: 0165-2478,

Authors: E.D. Carosella; J. Armand;

doi: 10.1016/0165-2478(89)90130-2

pmid: 2632372

IgC Fc fragments induce B cell differentiation and immunoglobulin secretion

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Abstract

We now show that the Fc fragment is capable of inducing B cell differentiation and secretion of immunoglobulins (Igs) in human mononuclear cells from peripheral blood (PBMC). The absolute number of plasma cells observed in all individuals tested is similar. However, in Ig secretion, we found two types of response: high responders and low responders

Keywords

B-Lymphocytes, Immunoglobulin G, Humans, Immunoglobulins, Cell Differentiation, In Vitro Techniques, Immunoglobulin Fc Fragments

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