Interleukin-2 receptors in infectious mononucleosis
Copyright policy )Interleukin-2 receptors in infectious mononucleosis
The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytometric immunofluorescence, and only a low level of specific interleukin-2 (IL-2) binding was found by Scatchard analysis. These results suggest that IL-2 receptors (IL-2R) are lost or down-regulated on activated T cells in acute IM. Since a large proportion of T cells die during the first 24 h of in vitro culture in the absence of exogenous IL-2, the data implicate a physiological role for the observed low levels of IL-2R on T cells.
- QIMR Berghofer Medical Research Institute Australia
- Royal Children's Hospital Australia
Kinetics, T-Lymphocytes, Humans, Interleukin-2, Receptors, Interleukin-2, Infectious Mononucleosis, In Vitro Techniques, Lymphocyte Activation
Kinetics, T-Lymphocytes, Humans, Interleukin-2, Receptors, Interleukin-2, Infectious Mononucleosis, In Vitro Techniques, Lymphocyte Activation
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